Results 81 to 90 of about 2,811,643 (287)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Shear buckling of specially orthotropic plates with centrally located cutouts [PDF]

The shear loading of a composite rectangular plate with a centrally located circular cutout was analyzed in order to predict the buckling load of the plate.
Klang, Eric C., Owen, Vicki
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Research on Robotic Peg-in-Hole Assembly Method Based on Variable Admittance

Applied Sciences
To address the complex challenge of identifying the contact state between a shaft and a hole and to improve the efficiency of robotic shaft-hole assembly tasks, a robotic shaft-hole assembly method based on variable admittance control is proposed.
Shenglun Zhang, Youchen Wang, Shuo Liang, Haobing Han, Zhouxiang Jiang, Meng Zhang   +5 more
doaj   +1 more source

Approximate likelihood inference in generalized linear latent variable models based on integral dimension reduction

, 2015
Latent variable models represent a useful tool for the analysis of complex data when the constructs of interest are not observable. A problem related to these models is that the integrals involved in the likelihood function cannot be solved analytically.
Bianconcini, Silvia, Cagnone, Silvia, Rizopoulos, Dimitris   +2 more
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

State estimation of variable frequency power grid of multi-electric aircraft based on adaptive enhanced complex-coefficient filter

Xibei Gongye Daxue Xuebao
The power grid of a multi-electric aircraft is a typical isolated island microgrid with a wide frequency range from 360 to 800 Hz. The dynamic performance of the traditional constant-frequency power grid synchronization method is insufficient in the ...
HU Xin, GUO Mengjie, ZHANG Zhen, MA Ruiqing, DUAN Chendong   +4 more
doaj   +1 more source

A Monte Carlo evolution of the Functional Resonance Analysis Method (FRAM) to assess performance variability in complex systems

Safety Science, 2017
Abstract Modern trends of socio-technical systems analysis suggest the development of an integrated view on technological, human and organizational system components. The Air Traffic Management (ATM) system can be taken as an example of one of the most critical socio-technical system, deserving particular attention in managing operational risks and ...
PATRIARCA, RICCARDO, DI GRAVIO, GIULIO, COSTANTINO, francesco   +2 more
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source