Results 211 to 220 of about 3,543,735 (284)

A Systematic Intelligent Optimization Framework for a Sustained-Release Formulation Design. [PDF]

Pharmaceutics
Qiao Y, Wu Y, Han M, Ren H, Cui Y, Wang X, Lou Y, Hao C, Feng Q, Qiu L.   +9 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Explainable artificial intelligence approaches for predicting depression by combining feature selection methods and machine learning classifiers. [PDF]

Digit Health
Kim MG, Lee KC, Lee K, Kim HU, Seo YW, Chae SW.   +5 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Unbiased inference for echocardiogram urgency prediction using double machine learning. [PDF]

PLoS One
Jiang Y, Zhang W, Huang YL, MacKenzie C, Li Q.   +4 more
europepmc   +1 more source

Optimizing regional innovation ecosystems through actor-environment coevolution: A dynamic configurational analysis from a CAS perspective. [PDF]

PLoS One
Pang H, Jiang Y, Wu L, Wang L.
europepmc   +1 more source

Research on the influencing factors of user engagement in tourism short video from the perspective of configuration. [PDF]

PLoS One
Li L, An H.
europepmc   +1 more source

Backward cloud transformation algorithm based on Kullback Leibler divergence. [PDF]

PLoS One
Xu X, Yu K, Fu J, Dong L, Guo H, He H, Zhang L.   +6 more
europepmc   +1 more source

Soft Measurement Modeling Method Based on Quality-Related Mixed Variational Autoencoder Regression. [PDF]

ACS Omega
Xu J, Yu B, Mo C, Fang K, Lin X.
europepmc   +1 more source