Results 121 to 130 of about 7,833,680 (354)

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen   +18 more
wiley   +1 more source

RAB39B Related Parkinsonism in an Italian Family: A Unique Use of Advanced Therapies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Parkinson's disease (PD) is a neurodegenerative disorder that may sometimes be caused by deleterious genetic variants. Among them, RAB39B polymorphisms are known as rare causes of early‐onset PD associated with intellectual disability (Waisman's syndrome).
Caterina Del Regno   +13 more
wiley   +1 more source

Bounds for the sums of zeros of solutions of $u^{(m)}=P(z)u$ where $P$ is a polynomial

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2011
The main purpose of this paper is to consider the differential equation $u^{(m)}=P(z)u$ $(m\geq 2)$ where $P$ is a polynomial with in general complex coefficients. Let $z_{k}(u),$ $k=1,2,\ldots$ be the zeros of a nonzero solution $u$ to that equation. We
Ting-Bin Cao, Kai Liu, Hong-Yan Xu
doaj   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan   +22 more
wiley   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo   +12 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte   +13 more
wiley   +1 more source

A Note on the (ℎ,𝑞)-Extension of Bernoulli Numbers and Bernoulli Polynomials

open access: yesDiscrete Dynamics in Nature and Society, 2010
We observe the behavior of roots of the (ℎ,𝑞)-extension of Bernoulli polynomials 𝐵(ℎ)𝑛,𝑞(𝑥). By means of numerical experiments, we demonstrate a remarkably regular structure of the complex roots of the q-extension of Bernoulli polynomials 𝐵(ℎ)𝑛,𝑞(𝑥). The
C. S. Ryoo, T. Kim
doaj   +1 more source

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