Results 221 to 230 of about 3,005,039 (283)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Copper Complexes: Main Mechanisms as Anticancer Agents. [PDF]

Molecules
Hangan AC, Oprean LS, Procopciuc LM, Dican L, Gog-Bogdan S, Lucaciu RL.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Chemoselective and stereoselective charge transfer dynamic quenching with triazacyclononane europium and terbium tetra-azatriphenylene complexes.

Dalton Trans
Wen X, Black DJ, Pal R, Parker D.
europepmc   +1 more source

Screening pertactin-specific antibodies and evaluating competitive epitope recognition by native mass spectrometry. [PDF]

Chem Sci
Gadallah MI, McConnell KA, Hager KM, James VK, Nguyen AW, Maynard JA, Brodbelt JS.   +6 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Double encapsulation of C₆₀, [6]CPP and Li⁺@C₆₀ inside a peropyrene-linked, CPP-based double nanohoop.

Org Chem Front
Ye L, Yang Y, Juríček M, Drewello T.
europepmc   +1 more source

Bioactivity of Novel Colchicine, Colchiceine, and 10-Methylthiocolchicine Complexes with Lithium, Sodium, and Potassium Chlorides: Experimental and Theoretical Studies. [PDF]

Int J Mol Sci
Kurek J, Kwaśniewska-Sip P, Jankowski W, Myszkowski K, Cofta G, Hoffmann M, Murias M, Kurczab R, Śliwa P.   +8 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Cyclometalated Ir(iii) complexes bridged by µ-OH and µ-3,5-bis(4-methoxyphenyl)-pyrazole ligands. [PDF]

RSC Adv
Mausami, Trivedi H, Patra R, Behere RP, Kuila B, Singh Patel SK, Pandey MD, Maiti B, Mahanti B.   +8 more
europepmc   +1 more source