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The transcriptional complexity of the TFIIH complex
Trends in Genetics, 2003Mutations in some subunits of the basal DNA repair and transcription factor II H (TFIIH) are involved in several human genetic disorders. Transcription factor II H interacts with a variety of factors during transcription, including nuclear receptors, tissue-specific transcription factors, chromatin remodeling complexes and RNA, suggesting that, in ...
Mario, Zurita, Carlos, Merino
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Groundwater, 2006
Abstract It is difficult to define complexity in modeling. Complexity is often associated with uncertainty since modeling uncertainty is an intrinsically difficult task. However, modeling uncertainty does not require, necessarily, complex models, in the sense of a model requiring an unmanageable number of degrees of freedom to ...
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Abstract It is difficult to define complexity in modeling. Complexity is often associated with uncertainty since modeling uncertainty is an intrinsically difficult task. However, modeling uncertainty does not require, necessarily, complex models, in the sense of a model requiring an unmanageable number of degrees of freedom to ...
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Cancer and bone: A complex complex
Archives of Biochemistry and Biophysics, 2014Primary and secondary bone cancers are rare events. However, once settled, a complex process is started involving an extensive amount of factors and interactions. The bone micro-environment is a preferential site for (metastatic) tumor cells to enter, stay, colonize and expand.
Driel, Marjolein, van Leeuwen, Hans
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The ethics of complexity and the complexity of ethics
South African Journal of Philosophy, 2012In this paper, we investigate the implications that a general view of complexity - i.e. the view that complex phenomena are irreducible - hold for our understanding of ethics. In this view, ethics should be conceived of as constitutive of knowledge and identity, rather than as a normative system that dictates right action.
Minka Woermann, Paul Cilliers
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2011
This is the core chapter of this book, about the complexity of complexity. After all of the rethinking in the preceding chapters, we think we are able to present a different notion and concept of complexity that can lead to a new way of thinking in complexity. We intend to develop a way of thinking in complexity that goes beyond the complexity as taken
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This is the core chapter of this book, about the complexity of complexity. After all of the rethinking in the preceding chapters, we think we are able to present a different notion and concept of complexity that can lead to a new way of thinking in complexity. We intend to develop a way of thinking in complexity that goes beyond the complexity as taken
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Complexities of the pyruvate dehydrogenase complex
Neurology, 1998If one were to throw a dart at the center of a biochemical chart for intermediary metabolism, it would land on acetyl-CoA. This metabolite is at the convergence of pyruvate, fatty acid, and ketone body metabolism. Condensation of acetyl-CoA with oxaloacetate forms citric acid, the entry point into the tricarboxylic acid cycle.
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Complexity, Complexities and Complex Knowledges
2017This discussion aims at exploring the consequences of the existence of different types of complexities in the study of socio-technical systems. We illustrate links between three different type of complexities, namely weak emergence in the sense of Bedau (2002), computational complexity and informational complexity.
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