Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Trends in the complexity of self-harm hospitalisations over 11 years at a major regional hospital in Victoria, Australia: a retrospective study. [PDF]
Mnatzaganian G+11 more
europepmc +1 more source
Characterization of the sequence complexity and organization of the Neurospora crassa genome
Robert Krumlau, George A. Marzluf
openalex +2 more sources
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu+12 more
wiley +1 more source
Analysis and Synchronous Study of a Five-Dimensional Multistable Memristive Chaotic System with Bidirectional Offset Increments. [PDF]
Ding L, Xuan M.
europepmc +1 more source
On tape-bounded complexity classes and multihead finite automata
I. Hal Sudborough
openalex +1 more source
Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
Improving the Protection of Step-Down Transformers by Utilizing Percentage Differential Protection and Scale-Dependent Intrinsic Entropy. [PDF]
Huang CW+4 more
europepmc +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Epistemological Foundation for the Use of the Linguistic Measures of the Referential Process. [PDF]
Negri A, Barazzetti A.
europepmc +1 more source