Results 101 to 110 of about 915,821 (290)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
MacHa: Multi-Aspect Controllable Text Generation Based on a Hamiltonian System
ComputersMulti-faceted controllable text generation can be viewed as an extension and combination of controllable text generation tasks. It requires the generation of fluent text while controlling multiple different attributes (e.g., negative emotions and ...
Delong Xu, Min Lin, Yurong Wang
doaj +1 more source
A New Fault Diagnosis Method Based on Attributes Weighted Neutrosophic Set
IEEE Access, 2019 Fault diagnosis is an extensively applied issue to monitor condition and diagnose fault for safe and stable operation of the machine, which started to develop during the industrial revolution and contains various theories and technologies.
Linfeng Gou, Yu Zhong
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Clustering Musik Rock Menggunakan Algoritma K-Means dan K- Medoids [PDF]
Clustering is a data analysis technique used to group objects with similar attributes or characteristics. The goal of clustering is to uncover hidden structures or patterns in data without prior label or classification information.
Andini, Cheria Rindang Tri
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Simulation of Mixed Critical In-vehicular Networks
, 2018 Future automotive applications ranging from advanced driver assistance to autonomous driving will largely increase demands on in-vehicular networks. Data flows of high bandwidth or low latency requirements, but in particular many additional communication
Korf, Franz +3 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source