Results 151 to 160 of about 673,074 (307)

User interface complexity reduction in training systems

open access: yesGMS Medizinische Informatik, Biometrie und Epidemiologie, 2006
Case based training systems are well accepted in medical education. The complexity of the used cases ranges from simple cases, where all symptoms and findings are presented at once and different questions concerning the diagnoses and/or therapies are to ...
Hörnlein, Alexander, Puppe, Frank
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Managing Complexity in Modern Farming

open access: yes
Modern farming in Australia is no longer simple. Farms are large, multi-enterprise businesses underpinned by expensive capital investments, changing production technologies, volatile markets and pervasive regulation.
Kingwell, Ross S.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

TEXT COMPLEXITY AND TEXT SIMPLIFICATION [PDF]

open access: yes, 2012
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyDue to the fact that emergency situations can lead to substantial losses, both financial and in terms of human lives, it
Temnikova, Irina
core  

Complexity Reduction of Biochemical Networks [PDF]

open access: yesProceedings of the 2006 Winter Simulation Conference, 2006
Ravishankar Rao Vallabhajosyula   +1 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Video encoder complexity reduction

open access: yes, 2005
Video encoder complexity reduction is a very active research area in the past 20 years. Many researchers have developed fast algorithms to reduce the com-putation complexity of video encoder in every aspects.
Chan, Ming-Yan
core  

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