Results 181 to 190 of about 673,074 (307)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pattern Recognition of Neurotransmitters: Complexity Reduction for Serotonin and Dopamine. [PDF]

Biosensors (Basel)
Nchouwat Ndumgouo IM, Devoe E, Andreescu S, Schuckers S.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Complexity Reduction Methods for Large-Scale Spatially Explicit Biofuels Network Design. [PDF]

Ind Eng Chem Res
Tran PM, O'Neill EG, Maravelias CT.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Complexity reduction by symmetry: Uncovering the minimal regulatory network for logical computation in bacteria. [PDF]

PLoS Comput Biol
Álvarez-García LA, Liebermeister W, Leifer I, Makse HA.   +3 more
europepmc   +1 more source

Complexity reduction in the use of evolutionary algorithms to function optimization: a variable reduction strategy. [PDF]

ScientificWorldJournal, 2013
Wu G, Pedrycz W, Li H, Qiu D, Ma M, Liu J.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Dynamic selection of ontological alignments: a space reduction mechanism

, 2009
Effective communication in open environments relies on the ability of agents to reach a mutual understanding of the exchanged message by reconciling the vocabulary (ontology) used.
Payne, Terry R., Tamma, Valentina, Palmisano, Ignazio, Doran, Paul   +3 more
core  

Expanding interpretability through complexity reduction in machine learning-based modelling of cardiovascular disease: A myocardial perfusion imaging PET/CT prognostic study. [PDF]

Eur J Clin Invest
Lehtonen E, Teuho J, Vatandoust M, Knuuti J, Knol RJJ, van der Zant FM, Juárez-Orozco LE, Klén R.   +7 more
europepmc   +1 more source