Results 61 to 70 of about 1,855,090 (310)

Effect Of Mirthful Laughter On Vascular Function [PDF]

, 2010
In contrast to the well-established scientific evidence linking negative emotional states (e.g., depression, anxiety, or anger) to increased risk for cardiovascular disease, much less is known about the association between positive emotional states (e.g.,
Sugawara, Jun, Tanaka, Hirofumi, Tarumi, Takahashi   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

High risk dental caries and patient compliance

Эндодонтия Today, 2020
Summing up the knowledge available at the present stage of medical development, we can conclude that the state of the dental apparatus can and should be considered as an indicator of the state of the body as a whole.
I. M. Voloshina, E. V. Belikova
doaj   +1 more source

Are we predisposed to behave securely? Influence of risk disposition on individual security behaviors [PDF]

, 2018
Employees continue to be the weak link in organizational security management and efforts to improve the security of employee behaviors have not been as effective as hoped.
Goel, Sanjay, Renaud, Karen, Warkentin, Merrill, Williams, Kevin J.   +3 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Compliance Risk Management of Investigator Initiated Trials on Children Rare Diseases: Medical Institution Perspective

罕见病研究
There is a substantial unmet need for treatments in the field of pediatric rare diseases, and investigator initiated trial(IIT) provide a critical pathway for testing and developing new drugs or treatment strategies.
ZHANG Jingqi, ZUO Liandong, GAO Xueqi, SI Wenyue, LUO Rui, WU Qiang, ZHOU Wenhao   +6 more
doaj   +1 more source

Causal inference in paired two-arm experimental studies under non-compliance with application to prognosis of myocardial infarction

, 2012
Motivated by a study about prompt coronary angiography in myocardial infarction, we propose a method to estimate the causal effect of a treatment in two-arm experimental studies with possible non-compliance in both treatment and control arms.
Abadie, Angrist, Bartolucci, Bartolucci, Bartolucci, Bertrand, Boden, Breslow, Cannon, Collett, Fox, Hirano, Holland, Hosmer, Imbens, Jin, McCullagh, McCullough, Pearl, Pearl, Ragmin, Robins, Robins, Robins, Rothaman, Rubin, Rubin, Rubin, Schwarz, Tan, Ten Have, TIMI III B Investigators, Vansteelandt, Vansteelandt, White, Yau   +35 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Theoretical open-loop model of respiratory mechanics in the extremely preterm infant [PDF]

, 2018
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease.
Brandes, Matthew, Fix, Laura Ellwein, Khoury, Joseph, Linkous, Lauren, Moores, Russell, Rozycki, Henry J.   +5 more
core   +4 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source