Results 91 to 100 of about 8,022,362 (339)
Geometric Construction-Based Realization of Spatial Elastic Behaviors in Parallel and Serial Manipulators [PDF]
, 2018 This paper addresses the realization of spatial elastic behavior with a parallel or a serial manipulator. Necessary and sufficient conditions for a manipulator (either parallel or serial) to realize a specific elastic behavior are presented and ...
Huang, Shuguang, Schimmels, Joseph M.
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
INFLUENCE OF DIFFERENT LIVING HINGES GEOMETRIES TO COMPLIANT STRAIGHT LINE MECHANISM TRAJECTORY
Journal of Industrial Design and Engineering GraphicsClassical straight-line mechanisms are one of the most interesting, both from a theoretical and practical point of view. In many cases, those mechanisms frequently produce a nearly straight trajectory rather than one perfectly straight.
Boris KOSIC +4 more
doaj +2 more sources
Analytical and numerical investigation of structural response of compliant wall materials [PDF]
Surface motion of compliant walls in drag reduction experiments was analyzed. The spectrum of surface motion indicates that membranes over deep cavities respond at low frequencies and large wavelengths.
Balasubramanian, R., Goglia, G. L.
core +1 more source
Managing standards compliance [PDF]
, 1999 Software engineering standards determine practices that `compliant' software processes shall follow. standards generally define practices in terms of constraints that must hold for documents.
Antonelli, S. +5 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
On Fodor on Darwin on Evolution [PDF]
, 2009 Jerry Fodor argues that Darwin was wrong about "natural selection" because (1) it is only a tautology rather than a scientific law that can support counterfactuals ("If X had happened, Y would have happened") and because (2) only minds can select.
Harnad, Stevan
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International Journal of Mechanical Sciences, 2022 Haitong Liang +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source