Results 111 to 120 of about 4,251,609 (342)
Mortality and secondary complications four years after traumatic spinal cord injury in Cape Town, South Africa [PDF]
, 2020 Vuyolwethu Madasa +3 more
openalex +1 more source
Physiological stress level and screening for malnutrition as preoperative predictors of postoperative complications in pancreatic surgery: a retrospective study [PDF]
, 2023 І. А. Кryvoruchko +7 more
openalex +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Nature Communications, 2019 Both insulin and IGF-1 signaling have been implicated in arterial intimal hyperplasia. Here the authors dissect the relative contributions of insulin and IGF-1 receptors, showing that homodimers of insulin receptors, but not IGF-1 receptor, induce ...
Qian Li +11 more
doaj +1 more source
Discordant Trends in Microvascular Complications in Adolescents With Type 1 Diabetes From 1990 to 2002 [PDF]
, 2005 Fauzia Mohsin +8 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Bleeding, Thrombosis and Vascular BiologyCardiovascular disease (CVD) remains the leading cause of mortality worldwide. Despite advancements in medical interventions, the burden of CVD continues to rise due to aging populations, lifestyle factors, and socio-economic disparities.
Ciarán Kennedy +3 more
doaj +1 more source
Risk Factors Associated With Perioperative Complications and Prolonged Length of Stay After Laparoscopic Adrenalectomy [PDF]
, 2018 Yufei Chen +8 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer
Epigenetics & Chromatin, 2019 Background Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC).
Parijat Senapati +10 more
doaj +1 more source