Results 11 to 20 of about 4,251,609 (342)

miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

open access: yesCommunications Biology, 2021
Kato, Abdollahi et al. identify a redox protein thioredoxin and mitochondrial fission-1 (FIS1) protein as miR-379 targets in mouse kidney. They find that miR-379 knockout mice are protected from diabetic kidney disease by enhancing mitophagy via FIS1 ...
Mitsuo Kato   +14 more
doaj   +1 more source

A cohort study of membranous nephropathy, primary or secondary

open access: yesBMC Nephrology, 2021
Background Although IgG4 deposit against phospholipase A2 receptor (anti-PLA2R) is predominantly presented in the renal biopsy of patients with primary membranous nephropathy (MN), its diagnostic value of this immune complex has not been fully ...
Maryam Arghiani   +7 more
doaj   +1 more source

Complications of frontal defects [PDF]

open access: yes, 1987
A case where the severe course of an orbital phlegmon led to a functionally and cosmetically poor condition is presented. Thirty-five years later, it was possible to achieve a satisfactory result through several operations performed with ...
Berghaus, Alexander, Schmidt, B.
core   +1 more source

Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease

open access: yesFrontiers in Endocrinology, 2022
BackgroundRoux-en-Y gastric bypass surgery (RYGB) improves biochemical and histological parameters of diabetic kidney disease (DKD). Targeted adjunct medical therapy may enhance renoprotection following RYGB.MethodsThe effects of RYGB and RYGB plus ...
William P. Martin   +12 more
doaj   +1 more source

Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT [PDF]

open access: yesDiabetes & Metabolism Journal, 2020
BackgroundEpithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the ...
Sundong Lin   +6 more
doaj   +1 more source

Extrahepatic complications of liver transplantation. [PDF]

open access: yes, 1985
The massive surgical assault associated with hepatic transplantation makes a high frequency of complications almost inevitable. In this review of 225 patient records, selected at random from cases of liver transplantation in Pittsburgh over a 2 1/2 year ...
Shaw, BW, Starzl, TE, Wood, RP
core   +1 more source

Endogenous FGF1 Deficiency Aggravates Doxorubicin-Induced Hepatotoxicity

open access: yesToxics, 2023
Doxorubicin (DOX) is a broad-spectrum antineoplastic agent that widely used in clinic. However, its application is largely limited by its toxicity in multiple organs. Fibroblast growth factor 1 (FGF1) showed protective potential in various liver diseases,
Chunjie Gu   +9 more
doaj   +1 more source

Supergravity Computations without Gravity Complications [PDF]

open access: yes, 2011
The conformal compensator formalism is a convenient and versatile representation of supergravity (SUGRA) obtained by gauge fixing conformal SUGRA. Unfortunately, practical calculations often require cumbersome manipulations of component field terms ...
Clifford Cheung   +5 more
core   +3 more sources

Bile Acid–Mediated Activation of Brown Fat Protects From Alcohol-Induced Steatosis and Liver Injury in MiceSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Alcohol-associated liver disease (AALD) is one of the most common causes of liver injury and failure. Limited knowledge of the mechanisms underlying AALD impedes the development of efficacious therapies.
Mingjie Fan   +15 more
doaj   +1 more source

Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy

open access: yesScientific Reports, 2022
In patients with diabetes, it has been suggested that physical exercise may reduce albuminuria and the progression of renal disease. However, the molecular mechanism by which physical exercise protects the kidney in diabetes remains poorly understood ...
Guilherme Pedron Formigari   +6 more
doaj   +1 more source

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