Results 11 to 20 of about 2,688,243 (319)

miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Communications Biology, 2021
Kato, Abdollahi et al. identify a redox protein thioredoxin and mitochondrial fission-1 (FIS1) protein as miR-379 targets in mouse kidney. They find that miR-379 knockout mice are protected from diabetic kidney disease by enhancing mitophagy via FIS1 ...
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T Fueger, David Chan, Rama Natarajan   +14 more
doaj   +1 more source

A cohort study of membranous nephropathy, primary or secondary

BMC Nephrology, 2021
Background Although IgG4 deposit against phospholipase A2 receptor (anti-PLA2R) is predominantly presented in the renal biopsy of patients with primary membranous nephropathy (MN), its diagnostic value of this immune complex has not been fully ...
Maryam Arghiani, Boshra Hasan Zamani, Fatemeh Nazemian, Sara Samadi, Malihe Saber Afsharian, Mahmoud Habibzadeh, Saeid Eslami, Mahin Ghorban Sabbagh   +7 more
doaj   +1 more source

Complications of circumcision in male neonates, infants and children: a systematic review. [PDF]

, 2010
BACKGROUND: Approximately one in three men are circumcised globally, but there are relatively few data on the safety of the procedure. The aim of this paper is to summarize the literature on frequency of adverse events following pediatric circumcision ...
Larke Natasha, Halperin, Daniel, Weiss Helen A, Schenker Inon, Schenker, Inon, Daniel Halperin, Weiss, Helen A, Helen A Weiss, Halperin Daniel, Inon Schenker, Larke, Natasha, Natasha Larke   +11 more
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Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT [PDF]

Diabetes & Metabolism Journal, 2020
BackgroundEpithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the ...
Sundong Lin, Lechu Yu, Yongqing Ni, Lulu He, Xiaolu Weng, Xuemian Lu, Chi Zhang   +6 more
doaj   +1 more source

Does the revised cardiac risk index predict cardiac complications following elective lung resection? [PDF]

, 2013
Background: Revised Cardiac Risk Index (RCRI) score and Thoracic Revised Cardiac Risk Index (ThRCRI) score were developed to predict the risks of postoperative major cardiac complications in generic surgical population and thoracic surgery respectively.
Pala Rajesh, Naidu, Babu V, Babu Naidu, Marshall, Andrea, Bishay, Ehab, Maninder Kalkat, Ehab Bishay, Kerr, Amy, Richard Steyn, Wotton, Robin, Kalkat, Maninder, Steyn, Richard, Naidu, Babu, Rajesh, Pala B, Amy Kerr, Andrea Marshall, Kalkat, Maninder S, Marshall, A. (Andrea), Rajesh, Pala, Robin Wotton   +19 more
core   +1 more source

Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease

Frontiers in Endocrinology, 2022
BackgroundRoux-en-Y gastric bypass surgery (RYGB) improves biochemical and histological parameters of diabetic kidney disease (DKD). Targeted adjunct medical therapy may enhance renoprotection following RYGB.MethodsThe effects of RYGB and RYGB plus ...
William P. Martin, Yeong H. D. Chuah, Mahmoud Abdelaal, Anders Pedersen, Daniel Malmodin, Sanna Abrahamsson, Michaela Hutter, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Carel W. le Roux, Neil G. Docherty   +12 more
doaj   +1 more source

Endogenous FGF1 Deficiency Aggravates Doxorubicin-Induced Hepatotoxicity

Toxics, 2023
Doxorubicin (DOX) is a broad-spectrum antineoplastic agent that widely used in clinic. However, its application is largely limited by its toxicity in multiple organs. Fibroblast growth factor 1 (FGF1) showed protective potential in various liver diseases,
Chunjie Gu, Zijuan Liu, Yingjian Li, Mei Yi, Simeng Wang, Xia Fan, Da Sun, Chi Zhang, Xiaoqing Yan, Guicheng Wu   +9 more
doaj   +1 more source

Relationship between plasma sialic acid and fibinogen concentration and incident micro-and macrovascular complications in type 1 diabetes [PDF]

, 2008
AIMS/HYPOTHESIS: Type 1 diabetes is associated with an increased risk of vascular complications. This increased risk could be explained by sialic acid and/or fibrinogen.
MICCOLI, ROBERTO, Pickup, J C, SOEDAMAH MUTHU SS, S. S. Soedamah-Muthu, J. H. Fuller, Chaturvedi, N, On behalf of EURODIAB PCS STUDY GROUP, CHATURVEDI N, Pickup, J.C., Fuller, J.H., Fuller, J H, FULLER JH, N. Chaturvedi, null null, PICKUP JC, J. C. Pickup, Soedamah-Muthu, S.S., Soedamah-Muthu, S S, Chaturvedi, N.   +18 more
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Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism

Scientific Reports, 2017
Vertical sleeve gastrectomy (VSG) produces sustainable weight loss, remission of type 2 diabetes (T2D), and improvement of nonalcoholic fatty liver disease (NAFLD).
Juan Du, Jingyan Tian, Lili Ding, Candi Trac, Brian Xia, Siming Sun, Dustin E. Schones, Wendong Huang   +7 more
doaj   +1 more source

Rural Tanzanian women's awareness of danger signs of obstetric complications. [PDF]

, 2009
\ud Awareness of the danger signs of obstetric complications is the essential first step in accepting appropriate and timely referral to obstetric and newborn care.
Carlstedt, Anders,, Carlstedt Anders, Andrea B Pembe, Darj, Elisabeth, Pembe, A.B, Nystrom, Lennarth,, Pembe, Andrea, Gunilla Lindmark, Darj Elisabeth, Urassa, David P, Carlstedt, Anders, Nyström Lennarth, Carlstedt, A., Urassa David P, Darj, Elisabeth,, Lindmark, Gunilla, Lindmark, Gunilla,, Urassa, David, Anders Carlstedt, Lindmark, G., Pembe, Andrea B, Lindmark Gunilla, Nyström, Lennarth, Pembe Andrea B, Urassa, D.P, Pembe, Andrea,, Darj, E, David P Urassa, Elisabeth Darj, Nyström, L., Lennarth Nyström   +30 more
core   +1 more source