Results 211 to 220 of about 4,843,847 (318)

An Ai-Supported Biostatistics E-Course Based on the Successive Approximation Model: Evaluation in Medical Education. [PDF]

Adv Med Educ Pract
Omarbekova N, Koichubekov B, Abdikadirova K, Sorokina M, Kharin A, Nurmaganbetova M.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Why Do Stunting Interventions Remain Unequal in Urban Areas? A Multivariate Analysis of Subdistrict Risk Profiles in Cirebon City, Indonesia. [PDF]

Risk Manag Healthc Policy
Saliaputri L, Ginanjar I, Handoko B.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Comprehensive Geriatric Assessment and Geriatric Interdisciplinary Team Care Model: An Integrated Model for Older Adults. [PDF]

J Multidiscip Healthc
Wu Y, Yang L, Sha Y, An Y, Li W, Hu X, Yang G, Chen X.   +7 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Pre-Procedural Robotic Surgery Curricula: A Systematic Review and Thematic Meta-Synthesis. [PDF]

Ann Surg Open
Devine M, Cullinane C, Mohan H, Kavanagh DO, O'Keeffe D, McGuire BB, Fleming CA.   +6 more
europepmc   +1 more source

Component-based Software development

, 2008
Component-based Software development is a promising way to improve quality, time to market and handle the increasing complexity of software management. However, The component-based development is still a process with many problems, it is not well de_ned either from theoretical or practical point of view.
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Development efficiency and mortality after coronary artery bypass grafting: a national causal inference analysis. [PDF]

J Cardiothorac Surg
Martins GK, Botelho AD, Consoli L, Grillo IT, Passos FS, Treml RE, Caldonazo T.   +6 more
europepmc   +1 more source