Results 91 to 100 of about 1,365,388 (312)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Evaluation of a Suite of Metrics for Component Based Software Engineering (CBSE) [PDF]

, 2009
V. Lakshmi Narasimhan, Prapanna Parthasarathy, Moumita Das   +2 more
openalex   +2 more sources

Evolutionary Multiobjective Approach for Multilevel Component Composition

Studia Universitatis Babes-Bolyai: Series Informatica, 2010
Component-based Software Engineering (CBSE) uses components to construct systems, being a means to increase productivity by promoting software reuse and increasing software quality.
Andreea Vescan, Crina Grosan
doaj  

Context-Aware Adaptation of Component-Based Systems: An Active Repository Approach

Journal of Computer Networks and Communications, 2012
Context-aware systems are able to monitor and automatically adapt their operation accordingly to the execution context in which they are introduced.
Sindolfo Miranda Filho, Julio Melo, Luiz Eduardo Leite, Guido Lemos   +3 more
doaj   +1 more source

Energy Management System Design for Good Delivery Electric Trike Equipped with Different Powertrain Configurations

World Electric Vehicle Journal, 2020
This paper demonstrates the design of an electric trike’s energy management system for a goods delivery service via various possible component configurations.
Iman K. Reksowardojo, Rafi R. Arya, Bentang A. Budiman, Metha Islameka, Sigit P. Santosa, Poetro L. Sambegoro, Abdul R. A. Aziz, Ezrann Z. Z. Abidin   +7 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Component-based software engineering [PDF]

, 2000
To solve the problems coming with the current software development methodologies, component-based software engineering has caught many researchers\u27 attention recently.
Wang, Zhiyuan
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A systematic review of applying modern software engineering techniques to developing robotic systems

Ingeniería e Investigación, 2012
Robots have become collaborators in our daily life. While robotic systems become more and more complex, the need to engineer their software development grows as well. The traditional approaches used in developing these software systems are reaching their
Claudia Pons, Roxana Giandini, Gabriela Arévalo   +2 more
doaj