Results 111 to 120 of about 383,435 (304)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Formal Approach for UML Components Based Development Profile

University of Sindh Journal of Information and Communication Technology, 2018
Component based software development CBSD is a very complex and difficult process, specifically modelling and integration of various components to make one complete running large system.
Arifa Bhutto, D.M. Akber Hussain, Imran Anwar Ujjan, Mehran Sayed   +3 more
doaj  

Advanced 3D-CAD Design Methods in Education and Research [PDF]

Journal of Systemics, Cybernetics and Informatics, 2009
The integration of advanced virtual engineering methods into 3D-CAD based development processes leads to increased requirements, concerning the software packages as well as regarding the applied procedures and strategies.
Mario Hirz, Alexander Harrich, Patrick Rossbacher   +2 more
doaj  

Subgraph Query for Building Service-Based Systems

IEEE Access, 2019
Given the broad applications of service-oriented architecture (SOA) in service-oriented software engineering, service-based systems (SBSs) built from existing Web services are becoming increasingly popular.
Jintao Wu, Xing Guo, Guijun Yang, Shuhui Wu, Haseeb Hassan, Jianguo Wu   +5 more
doaj   +1 more source

Incremental Learning from Multi-level Monitoring Data and Its Application to Component Based Software Engineering [PDF]

, 2017
Salman Taherizadeh, Vlado Stankovski
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

RAGE Architecture for Reusable Serious Gaming Technology Components

International Journal of Computer Games Technology, 2016
For seizing the potential of serious games, the RAGE project—funded by the Horizon-2020 Programme of the European Commission—will make available an interoperable set of advanced technology components (software assets) that support game studios at serious
Wim van der Vegt, Wim Westera, Enkhbold Nyamsuren, Atanas Georgiev, Iván Martínez Ortiz   +4 more
doaj   +1 more source

Component Based Systems: A Novel Methodology in Software Engineering [PDF]

, 2019
Usama Quadri Syed
openalex   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source