Results 171 to 180 of about 383,435 (304)

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Characterization of Muscle Fatigue Degree in Cyclical Movements Based on the High-Frequency Components of sEMG. [PDF]

Biomimetics (Basel)
Li K, Sun Y, Li J, Li H, Zhang J, Wang L.   +5 more
europepmc   +1 more source

Editorial to theme section on interplay of model-driven and component-based software engineering [PDF]

, 2020
Federico Ciccozzi, Antonio Cicchetti, Andreas Wortmann   +2 more
openalex   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Evaluation framework for domain-specific digital twin platforms. [PDF]

Sci Rep
Tang Z, Zhuang D, Zhang J.
europepmc   +1 more source

Research and application of key technologies for data delivery in railway engineering design based on metadata

High-Speed Railway
In view of the problems of inconsistent data semantics, inconsistent data formats, and difficult data quality assurance between the railway engineering design phase and the construction and operation phase, as well as the difficulty in fully realizing ...
Xiangru Lyu, Xunxiao Yin, Kun Wang, Yongwen Wei   +3 more
doaj  

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Optimizing alternate replacement strategy of k-out-of-n: F systems with common-mode degradation: An application to railway grid. [PDF]

PLoS One
Wang L, Ding M, Liu B, Qiu Q.
europepmc   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Entropy scaling for diffusion coefficients in fluid mixtures. [PDF]

Nat Commun
Schmitt S, Hasse H, Stephan S.
europepmc   +1 more source