Results 211 to 220 of about 307,163 (278)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Internal Density Calibration in the Proximal Humerus to Estimate Bone Stiffness for Stemless Shoulder Arthroplasty. [PDF]

J Orthop Res
Stiles CKA, Matheson BE, Athwal GS, Callaghan JP, Dickerson CR, Boyd SK, Knowles NK.   +6 more
europepmc   +1 more source

Application of Component-Based Analysis Patterns for Pattern-Based Reverse Engineering of Mobile Robot Software

, 2005
Dayang N. A. Jawawi, Safaai Deris
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Hybrid Intelligent Nonlinear Optimization for FDA-MIMO Passive Microwave Arrays Radar on Static Platforms. [PDF]

Micromachines (Basel)
Zhang Y, Li W, Yang B, Zhu C, Dong K.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

An open source platform to automate the design, verification, and manufacture of 3D printed microfluidic devices. [PDF]

Sci Rep
Goenner B, Temple S, Zapata S, Wakeham D, Snelgrove A, Gaillardon PE, Nordin GP, Gale BK.   +7 more
europepmc   +1 more source

A generic model for software size estimation based on component partitioning : a dissertation presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Software Engineering

, 1989
June Verner
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Generalized contrastive PCA is equivalent to generalized eigendecomposition. [PDF]

PLoS Comput Biol
Woller JP, Menrath D, Gharabaghi A.
europepmc   +1 more source