Results 41 to 50 of about 307,163 (278)
Buildings, 2023 The concrete-filled steel tubular (CFST) arch bridge has achieved significant development in recent years due to its unique mechanical performance and technical advantages. However, due to the lagging theoretical research compared to engineering practice,
Peiwen Shen, Yue Chen, Song Ma, Yong Yan
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Pluig 'n Train - A Component Based Approach [PDF]
Interaction Design and Architecture(s), 2010 Technology enhanced learning can look back on a comparably long tradition. Surprisingly, the software systems in this field are seldom constructed based on state-of-the art insights in software engineering.
Alke Martens +3 more
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Modelinės architektūros naudojimas kuriant komponentines programų sistemas
Informacijos Mokslai, 2009 Modelinė architektūra gana paplitusi, tačiau jos taikymai komponentinei paradigmai yra tik daliniai – neatsižvelgiama į reikalavimą atskirti komponentų ir komponentinių sistemų kūrimo procesus.
Vaidas Giedrimas
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Development of a Modular Software Architecture for Underwater Vehicles Using Systems Engineering
Journal of Marine Science and Engineering, 2022 This paper addresses the development of a modular software architecture for the design/construction/operation of a remotely operated vehicle (ROV), based on systems engineering.
Carlos A. Zuluaga +5 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
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A Model-Driven Co-Design Framework for Fusing Control and Scheduling Viewpoints
Sensors, 2018 Model-Driven Engineering (MDE) is widely applied in the industry to develop new software functions and integrate them into the existing run-time environment of a Cyber-Physical System (CPS).
Sakthivel Manikandan Sundharam +3 more
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FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
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A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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HACS: A Hybrid Framework for Continuous Flexible and Controlled Architecting
Acta Informatica Pragensia, 2017 Systems like e-voting, e-banking or e-health must offer flexibility to continuously meet technical and legal changing requirements and must at the same time guarantee robustness to respect their security and sensitivity.
Bentlemsan Khadidja +3 more
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