Results 61 to 70 of about 1,365,388 (312)
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Synthetic biology open language (SBOL) version 3.0.0
Journal of Integrative Bioinformatics, 2020 Synthetic biology builds upon genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems.
Baig Hasan +14 more
doaj +1 more source
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
An engineering process for security patterns application in component based models [PDF]
, 2013 International audienceSecurity engineering with patterns is currently a very active area of research. Security patterns - an adaptation of Design Patterns to security - capture experts' experience in order to solve recurrent security problems in a ...
Bouaziz, Rahma +2 more
core +2 more sources
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
A Component-Oriented Programming for Embedded Mobile Robot Software
International Journal of Advanced Robotic Systems, 2007 Applying software reuse to many Embedded Real-Time (ERT) systems poses significant challenges to industrial software processes due to the resource-constrained and real-time requirements of the systems.
Dayang N. A. Jawawi +2 more
doaj +1 more source
A systematic review of COTS evaluation and selection approaches [PDF]
Accounting, 2017 In the past decades, a number of researchers have made their significant contributions to develop different approaches for solving a very challenging problem of commercial off-the shelf (COTS) selection.
Rakesh Garg
doaj +1 more source
A Formal Architectural Description Language based on Symbolic Transition Systems and Modal Logic [PDF]
, 2006 International audienceComponent Based Software Engineering has now emerged as a discipline for system development. After years of battle between component platforms, the need for means to abstract away from specific implementation details is now ...
Poizat, Pascal, Royer, Jean-Claude
core +5 more sources
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Component-Based Java Legacy Code Refactoring
Revista Facultad de Ingeniería Universidad de Antioquia, 2013 Component-Based Software Engineering (CBSE) claims to improve software modularisation and to embed architectural concerns. Refactoring Java legacy code with CBSE in mind requires first assessing the compliance of legacy code with component programming ...
Hugo Arboleda +2 more
doaj +1 more source