Results 71 to 80 of about 307,163 (278)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Algebraic specifications and refinement for component-based development using RAISE
Journal of Computer Science and Technology, 2002 There are two main activities in Component-Based Development: component development, where we build libraries for general use, and component integration, where we assemble an application from existing components.
Elsa Clara Estévez +1 more
doaj
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Automated refactoring actions for performance improvement in component-based software engineering
, 2023 Daniele Di Pompeo, Michele Tucci
openalex +3 more sources
Development of Vacuum Vessel Design and Analysis Module for CFETR Integration Design Platform
Science and Technology of Nuclear Installations, 2016 An integration design platform is under development for the design of the China Fusion Engineering Test Reactor (CFETR). It mainly includes the integration physical design platform and the integration engineering design platform.
Chen Zhu +6 more
doaj +1 more source
Integrating Cyber-Physical Systems in a Component-Based Approach for Smart Homes
Sensors, 2018 Integration of different cyber-physical systems involves a development process that takes into account some solutions for intercommunicating and interoperating heterogeneous devices.
Javier Criado +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source