Results 71 to 80 of about 1,365,388 (312)

Microservices and Machine Learning Algorithms for Adaptive Green Buildings [PDF]

, 2019
In recent years, the use of services for Open Systems development has consolidated and strengthened. Advances in the Service Science and Engineering (SSE) community, promoted by the reinforcement of Web Services and Semantic Web technologies and the ...
Alonso Montesinos, Joaquín Blas, Ayala Palenzuela, Rosa María, Capobianco Uriarte, María De Las Mercedes, Criado Rodríguez, Javier, Iribarne Martínez, Luis Fernando, Piedra Fernández, José Antonio, Rodríguez Gracia, Diego   +6 more
core   +1 more source

An MDE approach for Runtime Monitoring and Adapting Component-based Systems: Application to WIMP User Interface Architectures [PDF]

, 2012
In certain systems, software must be adapted at runtime to the requirements and changes occurring in the context. A strategy to achieve this goal is to model such systems as software architectures making use of the Component-based Software ...
Criado, Javier, Iribarne, Luis, Padilla, Nicolás, Troya Castilla, Javier, Vallecillo Moreno, Antonio   +4 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Software reuse in industrial robotics: A systematic mapping

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2020
There is a tendency to use software reuse approaches in the domain of industrial robotic systems, to accelerate their development. Although some studies show the benefits of developing using different reuse approaches, these practices have not been ...
A. Solis, J. Hurtado
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Integration of Simulink Models with Component-based Software Models

Advances in Electrical and Computer Engineering, 2008
Model based development aims to facilitate the development of embedded control systems by emphasizing the separation of the design level from the implementation level.
MARIAN, N., TOP, S.
doaj   +1 more source

The failure tolerance of mechatronic software systems to random and targeted attacks

, 2013
This paper describes a complex networks approach to study the failure tolerance of mechatronic software systems under various types of hardware and/or software failures.
Dong, Andy, Kasthurirathna, Dharshana, Piraveenan, Mahendrarajah, Tumer, Irem Y.   +3 more
core   +1 more source

Business engineering building blocks [PDF]

, 2002
In order to utilize the contemporary advanced technology, business processes need sound software support. With respect to this, one frequent cause of software project failure is the mismatch between the business requirements and the actual ...
Shishkov, Boris
core   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source