Results 101 to 110 of about 420,621 (305)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Adaptive software synthesis from extended dataflow specifications = Síntese de Software Adaptativo baseada em Especificações Extended Dataflow

open access: yesActa Scientiarum: Technology, 2005
Embedded software development approaches used models of computationsuch as dataflow, discrete events, synchronous/reactive, among others. Due to the specialization of the existing models, each one can be better applied to a specific application domain ...
Ivanilton Polato   +1 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Desenvolvimento de sistema-protótipo de sinterização seletiva a laser, visando a obtenção de componentes com gradientes funcionais [PDF]

open access: yes, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Mecânica.Vários processos de produção são utilizados para obtenção de objetos, muitos destes impondo restrições quanto à ...
Kulman, Cristiano
core  

Incontinencia urinaria

open access: yesIatreia, 2002
Little is known about the natural evolution of the urinary incontinence as the age of beginning, the incidence rates, the advancement and the spontaneous remission.
Antonio José García López
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Avaliação da eficiência de um programa de contingências para desenvolvimento de comportamentos da classe "caracterizar comportamentos-objetivo" a profissionais de organização não-governamental do campo da educação [PDF]

open access: yes, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Psicologia, Florianópolis, 2013.Qual o papel das ONGs do campo da Educação?
Kawasaki, Hindira Naomi
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Bioactive compounds on food and health-promoting properties [PDF]

open access: yes, 2009
: Phytochemical substances are bioactive compounds that have special interest for scientist because of the health-promoting properties that have been demonstrated in scientific studies. Some consumers are interested to eat these products to be healthier;
Loaiza, María Camila   +10 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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