Results 141 to 150 of about 5,521,628 (314)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Experiences of generating COTS components when automating medicinal product evaluations [PDF]
, 2005 This paper reports on experiences of generating COTS components when designing and deploying component based software architecture for automation and interoperation of medicinal product evaluations across different countries in the world.
Milligan, P., Williams, S., Juric, R.
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Software Systems for Robotics An Applied Research Perspective
International Journal of Advanced Robotic Systems, 2008 Over the past 20 years, Defence Research and Development Canada has developed numerous teleoperated unmanned ground vehicles (UGV), many founded on the ANC?US command and control system.
Jack Collier +3 more
doaj
Development of polymer-derived ceramic sealing components
reservedAs industries increasingly prioritize sustainability and safety, the demand for alternatives to hazardous and polluting materials has grown. This research focuses on replacing tar-pitch, traditionally used in sealing components, with a safer ...
MOSCA, GIACOMO
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Contextualising components when addressing database interoperability
, 2004 The concepts of contextualising software components and role based modelling have been exploited when addressing the interoperability problem in multiple databases (DBs).
Paul, R.J., Juric, R., Kuljis, J.
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Image encoding by independent principal components
, 2010 The encoding of images by semantic entities is still an unresolved task. This paper proposes the encoding of images by only a few important components or image primitives. Classically, this can be done by the Principal Component Analysis (PCA). Recently,
Brause, Rüdiger W., Arlt, Björn
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Production of coated and free-standing engineering components using the HVOF (High Velocity Oxy-Fuel) process [PDF]
, 2003 The present study aims to establish the potential of producing various hard metal industrial thick components using the High Velocity Oxy-Fuel (HVOF) thermal spray process, rather than by sintering or casting techniques currently used.
Stokes, Joseph
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