Results 191 to 200 of about 386,145 (366)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Erratum: Data shadows: When data become tangible, material, and fragile. [PDF]

Patterns (N Y)
Trauttmansdorff P, Hajek KM.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Prospective Comparison of Large Language Models for Early Prediction of Sepsis. [PDF]

Pac Symp Biocomput
Shashikumar SP, Nemati S.
europepmc   +1 more source

Virtual Harp of Bach. Baroque.me by Alexander Chen between Net Art and Myth of the Great Composer

, 2018
Adriana Kretkowska
openalex   +2 more sources

Music, History, Autonomy, and Presentness: When Composers and Philosophers Cross Swords. Martin Kaltenecker and François Nicolas, eds. 2006. Penser l’oeuvre musicale au XX siècle: avec, sans ou contre l’histoire? Paris: Centre de documentation de la musique contemporaine. 134 pp. ISBN: 2-9516440-9-4 (paper) [PDF]

, 2009
Danick Trottier
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Business models and organizational roles of data spaces: A framework for value creation in data ecosystems. [PDF]

Data Brief
Gessler J, Cencic MR, Metzner C, Wieker H, Lindow K, Schulz WH.   +5 more
europepmc   +1 more source

The role of Vladyslav Zaremba’s composer heritage in the formation of a professional musician

Larysa Havrylenko, Yuriy Portnyi
openalex   +1 more source

An outstanding gerontologist. Artist. Composer. In memory of Academician of the National Academy of Sciences of Ukraine Vladyslav Viktorovych Bezrukov [PDF]

Vadim F. Sagach, M.M. Tkachenko
openalex   +1 more source