Results 291 to 300 of about 386,145 (366)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

La durée d’un code. [PDF]

CMAJ
Cameron R.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Crovalimab: a new era in paroxysmal nocturnal hemoglobinuria management. [PDF]

Ann Med Surg (Lond)
Waheed A, Gul MH, Wardak AB, Shabbir MUB, Touseef S, Zafar F, Hussaini H.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Score Images as a Modality: Enhancing Symbolic Music Understanding through Large-Scale Multimodal Pre-Training. [PDF]

Sensors (Basel)
Qin Y, Xie H, Ding S, Li Y, Tan B, Ye M.
europepmc   +1 more source

Closing the loop: establishing an autonomous test-learn cycle to optimize induction of bacterial systems using a robotic platform. [PDF]

Front Bioeng Biotechnol
Spannenkrebs JB, Eiermann A, Zoll T, Hackenschmidt S, Kabisch J.   +4 more
europepmc   +1 more source

An In-Person and Online Intervention for Parkinson Disease (UPGRADE-PD): Protocol for a Patient-Centered and Culturally Tailored 3-Arm Crossover Trial.

JMIR Res Protoc
Elpidoforou M, Grimani I, Papadopoulou M, Papagiannakis N, Bougea A, Simitsi AM, Sfikas E, Alexandratou I, Alefanti I, Antonelou R, Koros C, Mavroyianni I, Chrysovitsanou C, Stefanis L, Bakalidou D.   +14 more
europepmc   +1 more source

Advancing deep learning for expressive music composition and performance modeling. [PDF]

Sci Rep
Zhang M.
europepmc   +1 more source

Data shadows: When data become tangible, material, and fragile. [PDF]

Patterns (N Y)
Trauttmansdorff P, Hajek KM.
europepmc   +1 more source