Results 211 to 220 of about 5,737,097 (385)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Application of High-Performance Silver Nanowire and Metal Oxide Composite Electrodes as Window Electrodes in Electroluminescent Devices. [PDF]

Micromachines (Basel)
Yan X, Niu Z, Lyu M, Wang Y, Yang F, Wang C, Chi Y, Yang X.   +7 more
europepmc   +1 more source

Atlantic Pa/Th composite, new tropical Atlantic sedimentary Pa/Th data and age models

, 2018
Hong Chin Ng, Laura F. Robinson, Jerry F McManus   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Interfacial Bond Strength of CAD/CAM Resin Composites on Dentin vs. Composite Substrates: Influence of Dual-Cure and Self-Adhesive Resin Cements. [PDF]

Polymers (Basel)
Batgerel OE, Yazıcıoğlu O, Kıtın E, Gençel Bİ, Yamak F, Bozdağ SE, Sasany R.   +6 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Advanced Green Materials: Sustainable Cellulose-Lignin Composite Films Prepared via Ionic Liquid Processing. [PDF]

Polymers (Basel)
Madaj W, Puchalski M, Sulak K, Wawro D, Pabjańczyk-Wlazło E.   +4 more
europepmc   +1 more source

Degradation Properties of Sustained ReleaseMembrane Composited of Water-BasedCopolymer and Zeolite [PDF]

Haonan Sun, Lei Tao, Xianghong Guo, Jianxin Liu, Xihuan Sun, Juanjuan Ma   +5 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Study on the Dual Enhancement Effect of Nanoparticle-Surfactant Composite Systems on Oil Recovery Rates. [PDF]

Nanomaterials (Basel)
Li G, Huang B, Yuan Y, Fu C, Wang K.
europepmc   +1 more source