Results 141 to 150 of about 458,633 (327)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Composition, structure and properties of POPC–triolein mixtures. Evidence of triglyceride domains in phospholipid bilayers

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
We have in this study investigated the composition, structure and spectroscopical properties of multilamellar vesicles composed of a phospholipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and up to 10mol% of triolein (TO), a triglyceride. We found in agreement with previous results that the mixtures with 10mol% TO spontaneously separate
Duelund, Lars, Jensen, Grethe Vestergaard, Hannibal-Bach, Hans Kristian, Ejsing, Christer S., Pedersen, Jan Skov, Pakkanen, Kirsi Inkeri, Ipsen, John Hjort   +6 more
openaire   +3 more sources

On micro-structural effects in dielectric mixtures

, 2004
The paper presents numerical simulations performed on dielectric properties of two-dimensional binary composites on eleven regular space filling tessellations.
Bergman D J, Bergman D J, Bergman D J, Breiman L, Butkov E, Day A R, Day A R, Debye P, Dissado L A, Enis Tuncer, Feller W, Garnett J C M, Ghosh K, Golden K, Goncharenko A V, Goncharenko A V, Havriliak S, Ishida M, Jonscher A K, Landauer R J C Garland D B Tanner, Levy O, Levy O, Loéve M, Macdonald J R, Maxwell J C, McPhedran R C, McPhedran R C, Milton G W, Ngai K L, Perrins W T, Priou A, Ramakarishnan T V, Sahimi M, Sahimi M, Sihvola A, Sillars R, Stroud D, Torquato S, Tuncer E, Tuncer E, Tuncer E, Tuncer E, Tuncer E, Tuncer E, Tuncer E, Tuncer E Macdonald J R, Tuncer E Serdyuk Y V Guba?ski S M, Wagner K W, Wiener O, Williams R   +49 more
core   +2 more sources

Fabrication and Properties of Polypropylene and Kenaf Fiber Composite

IOP Conference Series: Materials Science and Engineering, 2018
The effect polypropylene maleic anhydride (PPMAH) as a compatibilizer in mixing of polypropylene (PP) with kenaf fiber (KP) has been studied. Seven (7) different PP/KF composites ratio (100/0, 95/5, 90/10, 85/15, 80/20, 75/25 and 70/30) where ...
Z. Mustaffa, S. Ragunathan, N. S. Othman, A. A. Ghani, W. A. Mustafa, A. M. Farhan, I. Zunaidi, Z. Razlan, W. K. Wan, A. Shahriman   +9 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Semi-interpenetrating polymer network for tougher and more microcracking resistant high temperature polymers [PDF]

, 1992
This invention is a semi-interpenetrating polymer network which includes a high performance thermosetting polyimide having a nadic end group acting as a crosslinking site and a high performance linear thermoplastic polyimide. An improved high temperature
Pater, Ruth H.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Determining conductivity and mobility values of individual components in multiphase composite Cu_(1.97)Ag_(0.03)Se [PDF]

, 2014
The intense interest in phase segregation in thermoelectrics as a means to reduce the lattice thermal conductivity and to modify the electronic properties from nanoscale size effects has not been met with a method for separately measuring the properties ...
Brown, David R., Day, Tristan W., Melot, Brent C., Snyder, G. Jeffrey, Zeier, Wolfgang G.   +4 more
core