A minimal cellulosome‐like system in Cellulosilyticum lentocellum
FEBS Open Bio, EarlyView.Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Mechanical Properties and Microstructure of Bonded Joints and Hybrid Structures with a 3D-Printed Honeycomb Core Modified with an Epoxy Matrix Filled with Recycled Polyurethane Foam. [PDF]
Materials (Basel)Penc M +7 more
europepmc +1 more source
Dual Composite Architectures for increased toughness at 1500°C
, 2016 A Dual Composite Architecture (DCA) is an engineered material with a composite structure on two different length scales. By engineering the property relationship of the primary architectures, the behavior of the DCA can be controlled, creating a material
R Grohsmeyer +3 more
core
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
Dough Rheology, Physico-Chemical, and Sensory Properties of Bread From Wheat/Fresh Green Mature Banana Puree Composite. [PDF]
Food Sci NutrMugampoza E +4 more
europepmc +1 more source
Effects of Mastic Ingredients and Composition on Asphalt Mixture Properties
, 2015 This master thesis purports to address the effects of different filler types in asphalt mastics and relate the differences to asphalt mixture properties and volumetric composition. Due to variations in properties for different filler types, e.g. particle size, density, mineral composition, Rigden voids, specific surface area and binder interaction, the
openaire +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source