Results 61 to 70 of about 140,782 (296)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

MODIFICATION OF COMPOSITE MIXTURES FOR MANUFACTURING SHIP CABLEWARE MATERIALS

Тонкие химические технологии, 2017
The purpose of this work was to develop a modified polymeric composite mixture for the manufacture of the outer shell of a ship's cable operating under conditions of aggressive environment and increased fire hazard. The performed research resulted in the
K. V. Raev, N. V. Chernousova
doaj   +1 more source

Crosslinking starch/oat hull mixtures for use in composites with PLA [PDF]

Polímeros, 2019
Modification of composite components has been proposed as a tool to improve their functional properties. The present work studied crosslinking of a starch/oat hull mixture by reactive extrusion with sodium trimetaphosphate (STMP), for application in ...
Thamires da Silva Peixoto, Fabio Yamashita, Ana Paula Bilck, Gizilene Maria Carvalho, Maria Victoria Eiras Grossmann   +4 more
doaj   +1 more source

A generalized mixture rule for estimating the viscosity of solid-liquid suspensions and mechanical properties of polyphase rocks and composite materials

, 2004
A simple phenomenological formula is proposed to predict the mechanical properties of isotropic multiphase materials in terms of component properties, volume fractions, and microstructures.
Ji, SC, Ji SC, Shaocheng Ji, Ji, Shaocheng   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Experimental analysis, predictive modelling and optimization of some physical and mechanical properties of aluminium 6063 alloy based composites reinforced with corn cob ash.

Journal of Materials and Engineering Structures, 2020
In the present work, aluminium alloy 6063 reinforced with various weight percentages of corncob ash (CCA) particles (2.5%, 5%, 7.5%, 10%, 12.5% and 15%) were prepared using stir casting process.
Benjamin Ufuoma ODONI, Francis Odikpo EDOZIUNO, Cynthia Chinasa NWAEJU, Richard O. AKALUZIA   +3 more
doaj  

Insights into the mechanism of phenolic mixture degradation by catalytic ozonation with a mesoporous Fe3O4/MnO2 composite

, 2016
A mesoporous Fe-3/MnO2 composite was fabricated by a co-precipitation method in this paper, and it showed a much higher activity than Fe3O4 and MnO2 in the catalytic ozonation of a p-cresol and p-chlorophenol mixture.
Nawaz, Faheem, Li, Yuping, Xiao, Jiadong, Cao, Hongbin, Xie, Yongbing, Zhang, Di   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source