Results 31 to 40 of about 2,341 (249)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
An Analysis of a Persian Archery manuscript written by Kapur Čand
The present article deals with an analysis of an undated Persian archery manuscript titled Resāle-ye Kamāndāri [Archery Manuscript] written by Kapur Čand. It is written in Persian and judging by the style it should have been written by a Persian. Persian
Bede Dwyer +1 more
doaj
Purpose. The Museum of Siberian Archaeology and Ethnography at Tomsk State University named after V. M. Florinsky (Tomsk) houses a unique item belonging to the “family of Central Asian” composite bows, which has no analogues among known items in terms of
R. M. Kharitonov, I. N. Korobeinikov
doaj +1 more source
Comprehensive study of the early Yakut Sergelyakh burial of the XV — beginning of the XVI centuries
The paper presents a comprehensive study of graves which relate to rare burial sites of the early stage of ethnic history of the Yakuts. The burial belongs to an equestrian warrior.
Bravina R.I. +11 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Development of a Morphing Landing Gear Composite Door for High Speed Compound Rotorcraft
In the framework of fast rotorcraft, smoothness and flushness of external aerodynamic surfaces present challenges for high-speed conditions, where aerodynamics is the driver of helicopter performance.
Antonio Chiariello +5 more
doaj +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
From primitive societies to today's modern armies, mankind has engaged in competition and warfare since its existence, developing various weapon systems for prevailing in these conflicts.
Oktay Gönültaş, Salih Parlak
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source

