Results 31 to 40 of about 6,720 (262)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Investigations of Bending Singularity Orders in a V-notched Composite Laminate Plate Based on the Ressiner-Mindlin Theory

MATEC Web of Conferences, 2018
In this paper, the bending singularity at the apex of a V-notched composite laminate plate is investigated. The anisotropy of the laminate is modeled by the Stroh formalism.
Chen Chung-De
doaj   +1 more source

Vibration characteristics of adhesive bonding repaired carbon fiber/epoxy laminate under hygrothermal condition

Journal of Aeronautical Materials, 2020
Through theoretical derivation and finite element simulation, the vibration characteristics of composite laminate with four-edge clamped support under hygrothermal condition were studied.
JIA Baohui, HAO Tongxing, ZHANG Gang, LU Xiang   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Stress Waves in Composite Laminates Excited by Transverse Plane Shock Waves

Shock and Vibration, 1996
A simple 1-dimensional model is presented to investigate elastic stress waves in composite laminates excited by underwater explosion shocks. The focus is on the elastic dynamic stress fields in the composite laminate immediately after the action of the ...
G.R. Liu, K.Y. Lam, E.S. Chan
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Peridynamic Open-Hole Tensile Strength Prediction of Fiber-Reinforced Composite Laminate Using Energy-Based Failure Criteria

Advances in Materials Science and Engineering, 2019
In the present study, peridynamic (PD) open-hole tensile (OHT) strength prediction of fiber-reinforced composite laminate using energy-based failure criteria is conducted. Spherical-horizon peridynamic laminate theory (PDLT) model is used.
Xiao-Wei Jiang, Hai Wang, Shijun Guo
doaj   +1 more source

Analytical modelling of laminated composites

Composites Science and Technology, 1993
This paper presents a unique approach to the analysis of thick laminated composites by presenting two simple finite element methods. The first uses the predictor corrector technique to extend the simple Mindlin-type element to achieve greater accuracy, and the second develops a new least squares element which can approximate a C(1) continuous element ...
Jeffrey V. Kouri, Satya N. Atluri
openaire   +2 more sources

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source