Results 151 to 160 of about 93,474 (312)

A rationally thin composite membrane with differentiated pore structure for industrial-scale alkaline water electrolysis

Nature Communications
Alkaline water electrolysis is one of the most prospective technologies for large-scale production of green hydrogen. Nevertheless, current porous membranes face the problem of weak ion transport or poor gas barrier performance.
Jian You, Jinyu Lu, Chuanli Liu, Wei Wang, Yongzhao Li, Yuanzhong Gao, Longmin Liu, Xiangbo Luo, Xiaojun Bao, Huaiyin Chen, Jianying Huang, Yuekun Lai, Meihua Wu, Weilong Cai   +13 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Fabrication and properties evaluation of chitosan/BaTiO3 composite membranes for the periodontitis treatment

Scientific Reports
Periodontitis gradually damages the hard and soft tissues surrounding the tooth, leading to tooth loss. In recent years, the use of biomaterials in periodontitis treatment has expanded, including gels, nanoparticles, microparticles, fibers, and membranes.
Aydin Houshyar, Mehdi Ahmadian, Yashar Azizian-Kalandaragh, Noushin Amirpour, Hossein Salehi   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Preparation and properties of graphene oxide composite forward osmosis membranes

Desalination and Water Treatment
To improve the water flux and antibacterial performance of graphene oxide (GO) forward osmosis membranes, pure GO forward osmosis membranes were first fabricated via a vacuum-assisted filtration method.
Yanyan Xu, Junming Zhao, Yonghong Zhang, Liliang He   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Current Density Performances in Poly Ether Ether Keton Membrane for Direct Methanol Fuel Cells [PDF]

, 2012
The objective of this study focuses on the characterization of poly ether ether ketone (PEEK) membranes for direct methanol fuel cells (DMFC) application. The PEEK membrane was modified with sulfonation in NMP solvent.
E. L. , Dewi, A. , Dhuhita, T. D. , Kusworo, M.N.A. , Mohd Norddin, D. K. , Arti, A.F. , Ismail   +5 more
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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Novel thin film composite membranes supported by cellulose triacetate porous substrates for high-performance forward osmosis [PDF]

, 2018
Novel thin film composite forward osmosis (TFC-FO) membranes were developed by using hydrophilic cellulose triacetate (CTA) porous substrates prepared by thermally induced phase separation (TIPS) method.
Gu, Lin, Xu, Zhi-Kang, Xing, Xiao-Yan, Yu, Yuan, Wu, Qing-Yun   +4 more
core