Results 51 to 60 of about 85,460 (265)

Antibacterial properties of marine algae incorporated polylactide acid membranes as an alternative to clinically applied different collagen membranes

Journal of Materials Science: Materials in Medicine
The reconstruction of bony defects in the alveolar crest poses challenges in dental practice. Guided tissue regeneration (GTR) and guided bone regeneration (GBR) procedures utilize barriers to promote bone regeneration and prevent epithelial growth. This
Jan-Tobias Weitkamp, Soumaya El Hajjami, Yahya Acil, Johannes Spille, Selin Sayin, Emine Sükran Okudan, Eyüp Ilker Saygili, Salih Veziroglu, Christian Flörke, Peter Behrendt, Jörg Wiltfang, Oral Cenk Aktas, Aydin Gülses   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Preparation of Polyvinyl Alcohol/Bacterial-Cellulose-Coated Biochar–Nanosilver Antibacterial Composite Membranes

Applied Sciences, 2020
Pathogenic bacteria and microorganisms in drinking water can cause various diseases, and new types of antibacterial material for water treatment and filtration are urgently needed.
Liang Zhang, Sen Zheng, Zhihui Hu, Lvling Zhong, Yao Wang, Xiaomin Zhang, Juanqin Xue   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Stable zeolitic imidazolate framework-8 supported onto graphene oxide hybrid ultrafiltration membranes with improved fouling resistance and water flux

Chemical Engineering Journal Advances, 2020
ZIF-8@GO composites were successfully synthesized through the in-situ growth method and were subsequently employed as fillers in low amounts of 0.1–0.5 wt% in the preparation of polyethersulfone (PES) ultrafiltration (UF) membranes via phase inversion ...
Thollwana Andretta Makhetha, Richard Motlhaletsi Moutloali   +1 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Impact of SiO2 Modification on the Performance of Nafion Composite Membrane

International Journal of Polymer Science
Using Nafion212 membrane and TEOS solution as raw materials, Nafion212/SiO2 composite membranes were prepared. In the in situ sol-gel reaction process, a series of Nafion/SiO2 composite membranes were prepared by varying the reaction temperature and ...
Shuangjie Liu, Jialin Yu, Yongping Hao, Feng Gao, Mo Zhou, Lijun Zhao   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source