Results 81 to 90 of about 124,379 (246)

An In-Depth Analysis of the Seismic Performance Characteristics of Steel–Concrete Composite Structures

open access: yesApplied Sciences
This review article provides an in-depth exploration of the recent advancements in the seismic analysis and design of steel–concrete composite structures, as reflected in the literature from the last ten years.
Panagiota Katsimpini   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

MODELLING OF UAV'S COMPOSITE STRUCTURES AND PREDICTION OF SAFETY FACTOR [PDF]

open access: yesApplied Computer Science, 2015
The paper presents possibilities of composite materials modeling using SolidWorks enviroment on example of Unmanned Aerial Vehicle wing structure. Mechanical properties of composite materials used in UAV's and process of modeling such structures in ...
Wojciech GRODZKI   +2 more
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Modelling and Production of Injection Moulded Polyvinylchloride--Sawdust Composite

open access: yesJournal of Applied Sciences and Environmental Management, 2020
This study focused on the modeling and production of the injection  moulded Polyvinylchloride-Sawdust (PVC-sawdust) composite. The PVC material and sawdust were mixed together to form a homogenous mixture with various percentage composition by volume as
C.O. Aliyegbenoma   +2 more
doaj   +2 more sources

Modeling Hysteretically Nonlinear Piezoelectric Composite Beams

open access: yesVibration
This paper presents a modeling framework for hysteretically nonlinear piezoelectric composite beams using functional differential equations (FDEs).
Abdulaziz H. Alazemi, Andrew J. Kurdila
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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