Results 111 to 120 of about 9,463,996 (246)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Research on vibration noise of the composite laminated plate structure based on the FEM-BEM
MATEC Web of Conferences, 2017 Based on the FEM-BEM hybrid method, the effects of the angle of composite layer, number of layers and the opening position of a composite material and opening form are studied in order to get these three aspects’ influence law on the vibration and ...
Xu Yang +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Characteristics of natural convection heat transfer in composite cavity
Case Studies in Thermal EngineeringIn order to study the influence of the nature of the mining airspace on the natural convection heat transfer in the unventilated working face, we establish a numerical model of natural convection in a composite cavity containing porous media by CFD ...
Changkui Lei +5 more
doaj +1 more source
Fabrication of 45S5 bioactive glass-polycaprolactone composite scaffolds
, 2009 45S5 bioactive glass-polycaprolactone composite porous scaffolds were produced using a solution blending and salt-leaching technique. The main target was the optimisation of the fabrication parameters (such as: blending conditions; nature and amount of ...
Fabbri P., Sola A., Cannillo V.
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
INTEGRAL OR DIFFERENTIAL DESIGN FOR A COST EFFECTIVE COMPOSITE AUTOMOTIVE BODY STRUCTURE
, 2014 The business case needs to be improved in order to make carbon fibre composites useful for the automotive industry. It is often claimed that one of composite greatest advantages over metals is the ability to be manufactured in large complex integral ...
Åkermo, Malin +2 more
core +2 more sources
Meteorological indices for potential occurrence of waterspout/tornado in Hong Kong
Meteorologische ZeitschriftAssessment of the potential occurrence of waterspouts and tornadoes in Hong Kong would be crucial in the timely alerting of these hazardous systems. This system provides for the first time a study of the meteorological parameters that may be useful to ...
Y.T. Leung +4 more
doaj +1 more source
Liquid Molding Innovation: Membrane-Based RTM and VIP Processing
, 2004 The University of Delaware Center for Composite Materials (UD-CCM) has discovered a Liquid Composite Molding (LCM) technique (patent pending) that significantly reduces resin waste while greatly improving robustness and part quality for Resin ...
Center for Composite Materials
core