Results 141 to 150 of about 14,326,834 (335)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Jixie chuandong, 2014 According to the basic structure characteristics of elastic composite cylindrical roller bearing,researches on dynamic radial stiffness of elastic composite cylindrical roller bearing are carried out in detail.The finite element analysis software is ...
姚齐水, 张然, 余江鸿, 杨文
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
AIP AdvancesDuring the present experimentation, milling machining was performed on two different composites, namely carbon fiber-reinforced polymer composite and jute fiber-reinforced polymer composite, using a computer numerical control vertical machining center ...
Murthy B. R. N. +6 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Highly Composite Numbers [PDF]
Proceedings of the London Mathematical Society, 1915 openaire +1 more source
Counting Composite and Prime Numbers
, 2020 Abstract: The set of positive integers can be divided into different sub-sets, such as the sets of even numbers, of odd numbers, of primes and of composites. Unlike the patterns for even numbers and odd numbers, no repetitive pattern has been identified for readily locating all the primes within the number line and hence by definition to readily locate
openaire +1 more source
Component-by-Component Construction of Good Lattice Rules with a Composite Number of Points
Journal of Complexity, 2002 F. Kuo, S. Joe
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source