Results 141 to 150 of about 325,156 (310)
Structural Health Monitoring of Composite Aircraft Structures Using Fiber Bragg Grating Sensors [PDF]
, 2013 Aircraft industry is continually striving towards reducing the acquisition, operation and maintenance costs. Usage of advanced composite materials in primary aircraft structures have resulted in significant weight savings owing to their higher specific ...
Nitesh, Gupta +6 more
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MicromachinesHigh-strength aluminium alloys are prone to porosity and cracking during laser-based powder bed fusion of metals (PBF-LB/M) due to the complex solidification behaviour, thus limiting the preparation of high-quality aluminium alloys.
Biao Huang +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2007 In this work, an analysis methodology for capturing the critical damage mechanisms leading to collapse in composite stiffened structures is proposed. One aspect of the methodology is a global-local analysis technique that monitors a strength criterion in
Thomson, Rodney +2 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Impact performance of embedded and co-cured composite damping panels
, 2011 The embedded and co-cured composite damping panels comprising of glass fiber layers and one (or more) damping layer(s) embedded into composite material components were designed and manufactured and these are presented in this paper.
Liang, Sen +1 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Potentials and Limitation of FE-based Simulation Methods for Fibre Composite Structures
, 2007 Current industrial demands for fibre composite primary structures in the area of aeronautics require innovative, experimentally validated simulation methods and tools, to support a cost and weight efficient design and to reduce their time-to-market ...
Luise Kärger +8 more
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