Results 171 to 180 of about 16,492,262 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Mesoscopic Inhomogeneities in Ethanol-Water Mixtures: Are They Nanobubbles, Impurity Aggregates, or Nanoscale Gas-Water Composite Structures? [PDF]

Langmuir
Chen CC, Hsu WH, Chen CJ, Yen TC, Chen CH, Chan CK, Hu CJ, Hwang IS.   +7 more
europepmc   +1 more source

Impact Resistance of Ultra-High-Performance Concrete Composite Structures. [PDF]

Materials (Basel), 2023
Ning H, Ren H, Wang W, Nie X.
europepmc   +1 more source

Effect of stress concentrations in composite structures [PDF]

The goal of achieving a better understanding of the failure of complex composite structure is sought. This type of structure requires a thorough understanding of the behavior under load both on a macro and micro scale if failure mechanisms are to be ...
Babcock, G. D., Knauss, W. G.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Progressive damage mechanism and multiscale characterization of hard sandstone-coal composite structures under loading. [PDF]

PLoS One
Dang J, Tu M, Zhang X, Bu Q.
europepmc   +1 more source

Analyses of composite structures [PDF]

Stiffness and strength analyses on composite cross-ply and helical wound cylinders and flat laminate ...
Adams, D. F., Doner, D. R., Tsai, S. W.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

PDMS-Epoxy Micro-Nano Composite Structures Constructed via Open-Loop Addition Reactions and Their Optical and Antifouling Performance Modulation. [PDF]

Materials (Basel)
Xu C, Chen X, Zhai S, Wang D, Zhu R.
europepmc   +1 more source

Out of plane analysis for composite structures [PDF]

Simple two dimensional analysis techniques were developed to aid in the design of strong joints for integrally stiffened/bonded composite structures subjected to out of plane loads.
Kan, Han Pin, Kautz, Edward F., Mahler, M. A., Paul, P. C., Saff, C. R., Sanger, Kenneth B.   +5 more
core   +1 more source