Results 171 to 180 of about 325,156 (310)

Coupled methods for detecting fatigue damage in thin-walled composite structures with different types of notches. [PDF]

Sci Rep
Różyło P, Paśnik J, Barski M, Stawiarski A, Romanowicz PJ, Chwał M.   +5 more
europepmc   +1 more source

Behaviour of concrete-filled steel tubular stub columns with different aggregates

, 2015
A series of tests on concrete-filled steel tubular (CFST) stub columns under axial compression was presented in this paper. Five different concrete mixes with the same cement content and water/cement ratio were designed using normal limestone aggregate ...
Tao, Zhong (R12091), Yu, Xin (S31676), Song, Tian-Yi (R17298)   +2 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantitative Damage Detection and Evolution in Composite Structures Using Digital Image Correlation, Machine Learning, and Peridynamics. [PDF]

Materials (Basel)
Vaitkūnas T, Jasiūnienė E, Griškevičius J, Samaitis V, Griškevičius P.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An Impact Load History Reconstruction Method for Composite Structures Based on FBG Sensing Data and the GCV Principle. [PDF]

Sensors (Basel)
Zeng J, Xu J, Xu Y, Zhao X, Wang S, Zhou Y, Wang Y.   +6 more
europepmc   +1 more source

Review and Assessment of Fatigue Delamination Damage of Laminated Composite Structures. [PDF]

Materials (Basel), 2023
Deng J, Zhou J, Wu T, Liu Z, Wu Z.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Deformation Prediction of 4D-Printed Active Composite Structures Based on Data Mining. [PDF]

Adv Sci (Weinh)
Wang M, Xu Y, Liu Z, Furukawa H, Wang Z, Xu R, Meng L.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source