Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Assessment of Digital Image Correlation Effectiveness and Quality in Determination of Surface Strains of Hybrid Steel/Composite Structures. [PDF]
Romanowicz PJ, Szybiński B, Wygoda M.
europepmc +1 more source
SEB: a computational tool for symbolic derivation of the small-angle scattering from complex composite structures. [PDF]
Jarrett TWJ, Svaneborg C.
europepmc +1 more source
Research on Lateral Resistance Performance of Prestressed Cross-Laminated Timber-Concrete Composite Structures under Reciprocating Loads. [PDF]
Xu Y +5 more
europepmc +1 more source
Investigation into the mechanical properties and impact tendency of coal-rock composite structures with peridynamics: A study on predicting the occurrence tendency of dynamic pressure in coal-rock structures. [PDF]
Dai J, Zhao M, Wang Z, Gao H.
europepmc +1 more source
Probability Prediction of Curing Process-Induced Deformation for V-Shape Composite Structures Based on FEM Method and Data Mining. [PDF]
Feng G, Liu B.
europepmc +1 more source
Fabrication and Application of Grinding Wheels with Soft and Hard Composite Structures for Silicon Carbide Substrate Precision Processing. [PDF]
Luo Q +5 more
europepmc +1 more source
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In the previous chapter, we started with drawing visual elements with and experimented with these elements in Processing, line by line. In this chapter, we move from the first step toward the second step: COMPOSITION AND STRUCTURE. The longer we experiment with visual elements and the more we discover about their properties, the more complex become the
Mathias Funk, Yu Zhang
openaire +1 more source

