Results 221 to 230 of about 1,068,348 (298)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Tensile and thermal properties of ceramic particulate and natural seaweed reinforced hybrid particulate polymer composites using the Taguchi approach. [PDF]
Sci RepKirubakaran R +4 more
europepmc +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Polyurethane Composite with Enhanced Mechanical and Damping Properties Filled with Surface-Grafted Hollow Poly(styrene-alt-maleic anhydride) Microsphere. [PDF]
Polymers (Basel)Xu R, Zhang J, Tian J, Jiang Z.
europepmc +1 more source
Antiplane magneto-electro-elastic effective properties of three-phase fiber composites
, 2014 Y. Espinosa-Almeyda +7 more
openalex +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Strategy Construction to Improve the Thermal Resistance of Polyimide-Matrix Composites Based on Fiber-Resin Compatibility. [PDF]
Materials (Basel)Xing Y, Ni H, Zhang D, Li J, Chen X.
europepmc +1 more source