Results 91 to 100 of about 7,797,494 (277)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Convex Cardinal Shape Composition
, 2015 We propose a new shape-based modeling technique for applications in imaging problems. Given a collection of shape priors (a shape dictionary), we define our problem as choosing the right dictionary elements and geometrically composing them through basic ...
Aghasi, Alireza, Romberg, Justin
core +1 more source
Designed Monomers and Polymers, 2020 In this paper, the ODOPM, a kind of 9, 10-dihydro-9-oxygen-heterooxy-10-phosphoro-10-oxygen (DOPO) derivative, was obtained by hydroxylation of DOPO.
Yazhen Wang +4 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Luminescent screen composition and apparatus [PDF]
, 1970 Ultraviolet light projects photographically produced images on a screen composed of a mixture of linear and nonlinear phosphors whose spectral emissions are different.
Hilborn, E. H.
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Fire resistant coating composition Patent [PDF]
, 1970 Fireproof potassium silicate coating composition, insoluble in water after ...
Schutt, J. B., Stuart, J. W.
core +1 more source
Is Architectural Drawing a Language? Symbols, Signs, Pictograms, Ideograms and Drawings
DiségnoArticulate language was established in the 20th century as the superior model of thought. It claimed a monopoly on the model of rational thought, even advocating a homomorphism between language and brain structure.
Angel Allepuz, Carlos L. Marcos
doaj +1 more source