Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The present-day chemical composition of the SMC from UVES spectra of the sharp-lined, B-type dwarf AV 304 [PDF]
W. R. J. Rolleston +3 more
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The Use of Sour and Sweet Whey in Producing Compositions with Pleasant Aromas Using the Mold Galactomyces geotrichum: Identification of Key Odorants [PDF]
Kamila Szudera-Kończal +3 more
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Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Vernacular heritage for an underlying principle of unity in the architectural process
How to learn from vernacular heritage and apply its lessons to contemporary architecture is not a recent concern. Admiration towards popular buildings can be traced back to key figures of the Modern Movement.
María Lidón de Miguel +3 more
doaj +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Nitrification in Mono Lake, California: Activity and community composition during contrasting hydrological regimes [PDF]
Stephen A. Carini, Samantha B. Joye
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This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk +3 more
wiley +1 more source
Chemical composition and in vitro antimicrobial and antioxidant activities of the essential oil of Nepeta nuda L. subsp. Albiflora (Boiss.) gams [PDF]
Ahmet Alim +5 more
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The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source

