Results 201 to 210 of about 11,337,621 (320)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

High Loss of Adipose Tissue During Neoadjuvant Chemotherapy Predicts Poor Prognosis in Patients With Gastric Cancer. [PDF]

J Cachexia Sarcopenia Muscle
He C, Zhu K, Guo Q, Chen L, Wu D, Lin L, Zhang X, Shen Q, Liu W, Zhang Q, Wang X, Hu P, Zheng Z, Wang X, Yan Z, Zhang Q, Shou C, Si Y, Wu X, Gao T, Gao Y, Yu J, Liu X.   +22 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

AI-derived body composition analysis reveals muscle volume and metformin-associated adipose effects and the obesity paradox in non-small cell lung cancer. [PDF]

EBioMedicine
Wang X, Hata A, Wada N, Song J, Fukuda T, Nakamura Y, Nishino M, Li Y, Schiebler ML, Christiani DC, Hatabu H.   +10 more
europepmc   +1 more source

ON THE COMPOSITION OF PELAGINE.

, 1895
Alden B. Griffith, Charles Platt
openalex   +2 more sources

Data_Sheet_1_Species Composition and Assemblages of Ichthyoplankton in Sansha Bay, Fujian Province, China.docx

, 2021
Yan Jiang (12139), Bai-an Lin (11801276), Hao-yang He (11801279), Guang-mao Ding (11801282), Li-ting Yan (11801285), Ge Zhang (112487), Min Liu (45756), Lian-ming Zheng (11801288)   +7 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Triaxial Electrospun Nanofiber Membranes for Prolonged Curcumin Release in Dental Applications: Drug Release and Biological Properties. [PDF]

Molecules
Tabakoglu S, Kołbuk D, Sajkiewicz P.
europepmc   +1 more source

Composition of 3.5 GPa Grade Maraging Steels and the Thermo-mechanical Treatments

, 1981
Hajime Sutô, Zhong Da Yin
openalex   +2 more sources

Data_Sheet_3_Investigating Heritage Language Processing: Meaning Composition in Chinese Classifier-Noun Phrasal Contexts.XLSX

, 2021
Fei Li (143236), Xiangfei Hong (11848826), Zhaoying He (11848829), Sixuan Wu (6645524), Chenyi Zhang (2644717)   +4 more
openalex   +2 more sources