Results 201 to 210 of about 8,434,398 (277)

Assessment of body fat percentage in Emirati females: a comparative analysis of BIA vs. DXA. [PDF]

Front Nutr
Haroun D, Ehsanallah A.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Childhood obesity, dietary patterns and gut microbiota: a narrative review. [PDF]

J Physiol Biochem
Vázquez-Bolea N, Navas-Carretero S, Cuervo M.   +2 more
europepmc   +1 more source

A Mediterranean dietary pattern intervention does not improve cardiometabolic risk but does improve quality of life and body composition in an Aotearoa New Zealand population at increased cardiometabolic risk: A randomised controlled trial [PDF]

Jeremy Krebs, Amber Parry‐Strong, Andrea Braakhuis, Anna Worthington, Troy L. Merry, Richard B. Gearry, Meika Foster, Mark Weatherall, Cheryl Davies, Jane Mullaney, Cecilia Ross, Denise Conroy, Anna Rolleston, Fiona E. Lithander   +13 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Learning in higher dimensions: a strategy for alloy electrocatalyst discovery.

EES Catal
Mints VA, Pedersen JK, Wiberg GKH, Edelvang-Pejrup J, Gautam D, Jensen KMØ, Rossmeisl J, Arenz M.   +7 more
europepmc   +1 more source

Nutritional Status, Body Composition and Growth in Paediatric-Onset Ulcerative Colitis: A Systematic Review. [PDF]

Nutrients
Sarbagili-Shabat C, Timmer F, Morogianni K, de Vries R, de Meij T, van der Kruk N, Verstoep L, Wierdsma N, Van Limbergen J.   +8 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Stator structure and subunit composition of the V 1 /V 0 Na + -ATPase of the thermophilic bacterium Caloramator fervidus 1 1Edited by W. Baumeister [PDF]

, 2000
T Ubbink-Kok, Egbert J. Boekema, Jan F. L. van Breemen, Alain Brisson, Wil N. Konings, Juke S. Lolkema   +5 more
openalex   +1 more source