Results 41 to 50 of about 2,962,628 (305)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Supercyclic Weighted Composition Operators on the Space of Smooth Functions

open access: yesMathematics
A weighted composition operator on the space of scalar-valued smooth functions on an open subset of a d-dimensional Euclidean space is supercyclic if and only if it is weakly mixing, and it is strongly supercyclic if and only if it is mixing.
Juan Bès, Christopher Foster
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The Composition operator on hardy space H2 Induced by ?(z)=sz+t where , and

open access: yesمجلة بغداد للعلوم, 2010
We study in this paper the composition operator of induced by the function ?(z)=sz+t where , and We characterize the normal composition operator C? on Hardy space H2 and other related classes of operators.
Baghdad Science Journal
doaj   +1 more source

Composition Operators Belonging to Operator Ideals

open access: yesJournal of Mathematical Analysis and Applications, 1999
Let \(D\) be the unit disc \(\{z\in\mathbb{C}:|z|< 1\}\) of the complex plane \(\mathbb{C}\), and let \(\mu\) be the normalized Lebesgue measure on \(D\).
openaire   +2 more sources

Spectra of Compact Composition Operators [PDF]

open access: yesProceedings of the American Mathematical Society, 1975
Let ϕ \phi be holomorphic and map the ...
Caughran, James G., Schwartz, Howard J.
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Approximation numbers of composition operators on Hp [PDF]

open access: yes, 2015
We give estimates for the approximation numbers of composition operators on the Hp spaces, 1 ≤ p < ∞
Queffélec Hervé   +9 more
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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