Results 61 to 70 of about 24,840,318 (307)

Compositional data, Bayesian inference and the modeling process [PDF]

, 2011
Statistical modeling in practice encompasses both the exploratory process, which is an inductive scientific approach and the confirmatory modeling process, which uses the deductive scientific approach.
Bacon-Shone, J, Bacon-Shone, J.
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Composite Repetition-Aware Data Structures [PDF]

, 2015
In highly repetitive strings, like collections of genomes from the same species, distinct measures of repetition all grow sublinearly in the length of the text, and indexes targeted to such strings typically depend only on one of these measures. We describe two data structures whose size depends on multiple measures of repetition at once, and that ...
Belazzougui, Djamal, Cunial, Fabio, Gagie, Travis, PREZZA, NICOLA, Raffinot, Mathieu   +4 more
openaire   +6 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Variability analysis of monthly precipitation vector time series in Australia by a new spatiotemporal entropy statistic

Environmental Research: Climate, 2023
Changing climate in Australia has significant impacts on the country’s economy, environment and social well-being. Addressing such impacts, particularly that of precipitation change, entails immediate action due to the more frequent occurrence of extreme
Benjamin Hines, Guoqi Qian, Tingjin Chu, Antoinette Tordesillas   +3 more
doaj   +1 more source

Data for: Post-wildfire denudation assessed from compositional features of river sediments (Central Portugal)

, 2020
Mineralogy data for the manuscript "Post-wildfire denudation assessed from compositional features of river sediments (Central Portugal ...
Dinis, Pedro, Dinis, P (via Mendeley Data)   +1 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Compositional Data and Microbiota Analysis: Imagination and Reality

Microorganisms
The relationships among bacterial flora, diseases, and diet have been described by many authors. An operational taxonomic units (OTUs) are the result of clustering the 16S rRNA gene sequences at a certain cutoff value, and they are considered ...
Tatsuki Itagaki, Hirokazu Kobayashi, Ken-ichiro Sakata, Ikuya Miyamoto, Akira Hasebe, Yoshimasa Kitagawa   +5 more
doaj   +1 more source

Compositional Data Analysis in Time-Use Epidemiology

, 2021
How we allocate time to activities impacts our health. Daily times spent in activities are interrelated because they compete for time-shares within a finite 24 h window.
Timothy Olds, Martín-Fernández, Josep Antoni, Dorothea Dumuid, Dumuid, Dorothea, Hron, Karel, Olds, Timothy, Karel Hron, Javier Palarea-Albaladejo, Pedišić, Željko, Palarea-Albaladejo, Javier, Josep Antoni Martín-Fernández, Željko Pedišić   +11 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source