FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
Explainable artificial intelligence for molecular design in pharmaceutical research. [PDF]
Chem SciLamens A, Bajorath J.
europepmc +1 more source
Asymptotic Behaviour of Compound Distributions and Stop-loss Premiums
ASTIN Bulletin: The Journal of the International Actuarial Association, 1982 B. Sundt
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
On-DNA Platform Molecules Based on a Diazide Scaffold II: A Compact Diazide Platform Designed for Small-Molecule Drug Discovery. [PDF]
Int J Mol SciMiyachi H, Koshimizu M, Suzuki M.
europepmc +1 more source
Higher-order expansions for compound distributions and ruin probabilities with subexponential claims
, 2010 H. Albrecher, C. Hipp, D. Kortschak
semanticscholar +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
A meta-learning framework to mitigate negative transfer in transfer learning applicable to drug design. [PDF]
Sci RepMera A, Vogt M, Bajorath J.
europepmc +1 more source
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Adaptive Label Refinement Network for Domain Generalization in Compound Fault Diagnosis. [PDF]
Sensors (Basel)Du Q, Yao J, Yang J, Tu F, Yang S.
europepmc +1 more source