Results 221 to 230 of about 9,320,217 (335)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases. [PDF]

Elife
Liu J, Shah A, Liu X, Wort JL, Ma Y, Hardman K, Johansson NG, Ribeiro O, Brookfield A, Bowen A, Yli-Kauhaluoma J, Xhaard H, Jeuken LJC, Goldman A, Pliotas C, Vidilaseris K.   +15 more
europepmc   +1 more source

ORDERING OF RISKS AND WEIGHTED COMPOUND DISTRIBUTIONS

, 1986
M. Goovaerts, M. Vandebroeck, R. Kaas
semanticscholar   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

DiaNat-DB-v2: A Molecular Database of Antidiabetic Compounds from Medicinal Plants and Functional Foods. [PDF]

ACS Omega
De Jesús-Reyes N, García-Vázquez J, Avellaneda-Tamayo JF, Ramírez-Palma D, Davari MD, Madariaga-Mazón A, Ovalle-Magallanes B, Medina-Franco JL, Martinez-Mayorga K.   +8 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Machine-learning and simulation identify food-derived xanthine oxidase inhibitors with in-vitro activity. [PDF]

Sci Rep
Yu B, Qin Z, Wu Y, He C.
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Machine learning prediction of multiple distinct high-affinity chemotypes for α-synuclein fibrils.

Chem Commun (Camb)
Li X, Perez RM, Tu Z, Mach RH, Giannakoulias S, Petersson EJ.   +5 more
europepmc   +1 more source