Results 51 to 60 of about 7,327 (245)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A multiple improved envelope spectra via feature optimization gram (MIESFO-gram) for diagnosis of compound fault signatures

Mechanics & Industry
Detecting compound faults in rotating machinery is challenging for fault diagnosis due to simultaneous occurrences of multiple faults, hindering the isolation of specific fault signatures.
Yazdanianasr Mahsa, Mauricio Alexandre, Gryllias Konstantinos   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Analyzing Vibration Mechanism of Angular Contact Ball Bearing with Compound Faults on Inner and Outer Rings

Shock and Vibration, 2021
This paper investigates a method to dynamically model compound faults on the inner and outer rings of an angular contact ball bearing as well as their effects on its dynamic behavior.
Lihai Chen, Ma Fang, Ming Qiu, Yanfang Dong, Xiaoxu Pang, Junxing Li, Chuanmeng Yang   +6 more
doaj   +1 more source

The observation of stacking-fault tetrahedra in III-V compounds

Philosophical Magazine Letters, 1987
Abstract The first observations of stacking-fault tetrahedra in ion-implanted III-V compounds are reported. The structure and orientation of the stacking-fault tetrahedra are briefly described. The tetrahedra are present in the near-surface region that recrystallized during the annealing.
B. C. De Cooman, S. McKernan, C. B. Carter, J. R. Ralston, G. W. Wicks, L. F. Eastman   +5 more
openaire   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Application of improved FastICA algorithm in compound fault diagnosis of vibrating scree

Gong-kuang zidonghua, 2017
In view of problem that common fault characteristic extraction methods could not extract compound fault characteristic completely and effectively, an improved fast independent component analysis(FastICA) algorithm was proposed.
XU Yuanbo, CAI Zongyan
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Spiking Neural Network with Attention and Residual Mechanisms for Compound Fault Detection

Machines
To address the challenges of severe multi-source coupling, easily masked spiking features, and limited selection of key responses in compound fault signals, this paper proposes a compound fault detection method based on a spiking attention residual ...
Yulong Xing, Kun Li, Xiaoshuai Li, Congcong Liu, Qi Wang, Cong Peng, Zisheng Wang   +6 more
doaj   +1 more source